📄 Category

cardiovascular medicine

117 papers

Cardiovascular medicine focuses on the heart and blood vessels, exploring how to prevent, diagnose, and treat conditions that affect our circulation. This vital field ranges from understanding high blood pressure and heart failure to investigating the latest breakthroughs in surgical techniques and lifestyle interventions. Because these discoveries directly impact public health, staying informed about emerging research is more important than ever for both specialists and curious readers.

At Gist.Science, we process every new preprint in this category as it appears on medRxiv, ensuring you have immediate access to the latest findings before they undergo formal peer review. For each study, we provide both a plain-language explanation to clarify the core concepts and a detailed technical summary for those seeking deeper scientific context. Below are the latest papers in cardiovascular medicine, organized to help you navigate the most recent developments shaping the future of heart health.

📄 cardiovascular medicine

Procedure-Specific Long-Term Thromboembolic Risk Associated With Postoperative Atrial Fibrillation After Cardiac Surgery: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis suggests that postoperative atrial fibrillation is associated with a significantly higher long-term thromboembolic risk following isolated valve surgery compared to coronary artery bypass grafting, although the finding requires further validation due to the limited number of included studies.

Ullah, A.2026-08-25
📄 cardiovascular medicine

Public interest in postural orthostatic tachycardia syndrome in the United Kingdom, 2004-2026: a Google Trends infodemiology study

This Google Trends infodemiology study reveals that public search interest in Postural Orthostatic Tachycardia Syndrome (POTS) in the United Kingdom experienced a sharp, sustained increase following the onset of the COVID-19 pandemic, with a notable shift toward diagnostic and self-assessment queries that suggests growing public awareness and self-investigation rather than a direct reflection of disease incidence.

Bogle, R. G., Bogle, C. M.2026-08-24
📄 cardiovascular medicine

Prospective evaluation of a self-report-guided strategy for targeted coronary artery calcium imaging

The prospective PRIO-Now study demonstrated that a self-report-based screening strategy effectively identified individuals with a high probability of significant coronary artery calcium, showing strong agreement between predicted and observed prevalence while revealing substantial opportunities for initiating preventive lipid-lowering therapy.

Hagberg, E., Björnson, E., Adiels, M., Daka, B., Fornander, L., Kjelldahl, J., Molnar, D., Pirazzi, C., Strömberg, U. (…)2026-08-19
📄 cardiovascular medicine

Cardiometabolic pathways linking genetically proxied educational attainment to cardiovascular disease: a Mendelian randomisation, mediation and colocalisation study

This study demonstrates that the increased cardiovascular disease risk associated with lower educational attainment is predominantly mediated (63–82%) by modifiable cardiometabolic risk factors such as obesity, hypertension, and diabetes, suggesting that targeted management of these conditions could significantly reduce socioeconomic health inequalities.

Le, N. N., Padmanabhan, S.2026-08-19
📄 cardiovascular medicine

Global genomics in over 4 million individuals prioritizes therapeutic targets for heart failure and its subtypes

This study leverages multi-ancestry genomic data from over 4 million individuals to identify hundreds of novel genetic loci and druggable targets for heart failure and its subtypes, highlighting the critical role of metabolic pathways and supporting the expansion of existing therapies like aldosterone synthase inhibitors and type-II activin receptor antagonists.

Rasooly, D., Peloso, G. M., Giambartolomei, C., Nicholls, H. L., Liu, C., Aung, N., Dashti, H., Gravel-Pucillo, K., Beru (…)2026-08-17
📄 cardiovascular medicine

The Current State of Timely Results Reporting Among Hypertension Trials on ClinicalTrials.gov: A Cross-Sectional Meta-Research Analysis

This cross-sectional meta-research analysis of 5,851 hypertension trials on ClinicalTrials.gov reveals that timely results reporting remains uncommon (9.1%), with compliance significantly higher only among studies meeting observable regulatory obligations, particularly those involving US sites.

Harris, W. T., Bragg, P., Kocour, L., Livsey, T., Langerman, R., Calvert, N., Lackey, M., Nguyen, A., Ford, A., Vassar (…)2026-08-07
📄 cardiovascular medicine

Efficacy and safety of PCSK9 inhibitors for children and adolescents with heterozygous familial hypercholesterolaemia: Systematic review and meta-analysis of randomised controlled trials

This systematic review and meta-analysis of three randomized controlled trials demonstrates that adding PCSK9 inhibitors to standard lipid-lowering therapy significantly reduces LDL-C levels in children and adolescents with heterozygous familial hypercholesterolaemia without compromising safety, though further long-term studies are needed to confirm sustained effectiveness and safety.

Llewellyn, A., Simmonds, M., Marshall, D., Harden, M., Humphries, S. E., Woods, B., Gomes, M., Priestley-Barnham, L., Ra (…)2026-08-06
📄 cardiovascular medicine

Ethnic and sex inequalities in premature coronary artery disease across disaggregated South Asian and Black subgroups in England: a population-based cohort study

This population-based cohort study reveals that aggregated ethnic categories mask significant sex-specific disparities in premature coronary artery disease risk across South Asian and Black subgroups in England, with Bangladeshi men facing the highest risk and current screening programs starting too late to effectively target these high-risk groups.

Natarajan, N., Parker, S. R., Quill, S., Diamondali, S., Rathod, K., Choudry, F., Joshi, A., Engmann, J., Schmidt, A. F. (…)2026-08-05
📄 cardiovascular medicine

Stress-Related Methylation Risk Scores Predict Coronary Heart Disease

This study demonstrates that DNA methylation risk scores derived from stress-related epigenetic signatures in postmenopausal women serve as novel biomarkers that predict incident coronary heart disease and mediate a significant portion of the stress-disease association, with monocytes identified as a key cellular mechanism.

Benavides, S., Milla, H., Palma-Gudiel, H., Checknita, D., Tuftin, B., Xia, K., Kooperberg, C., Reiner, A. P., Manson, J (…)2026-08-03